em. p. benoit pernicious anemia

pernicious anemia

true addison anemia
megaloblastic (nutritional) anemias

D G Cameron
GM Watson
LJ Witts

GEORGE R. MINOT, M.D.; WILLIAM P. MURPHY, M.D.

Dr. William P. Murphy
"Dr. George Whipple of the University of Rochester

William P. Murphy

G L Stark, P J Hamilton, Department of Haematology, Royal Victoria
Infirmary, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP, UK
Correspondence to: Dr G L Stark, Department of Haematology, Royal
Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP,
UK; g.l.stark@ncl.ac.uk
\

White European

Edward L Rickes - Merck Rahway

Official account of the Pernicious Anaemia Society. Volunteer-run charity based in South Wales.

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Martyn Hooper

Historical Events in Pernicious Anemia
1855: Thomas Addison: Describes an unusual anemia in preface to
monographon adrenal insufficiency.
1880: Paul Ehrlich: Described megaloblasts in the blood.
1883: Otto Leichtenstem: Described postero-lateral spinal column
degeneration.
1887: GeorgeS. Hayem: Described macrocytes in blood.
1897: William Hunter: Emphasized presence of sore tongue.
1907: Joseph Ameth: Described multilobed PMN's
1908: Richard Cabot: Defined entire clinical picture in 1200 patients he
studied.
1926: George Minot, William Murphy: Anemia abolished by diet (112lb
lightly cooked beef liver per day). (Presented at AAP on May 4, 1926.
Nobel Prize: 1934)
1928: Edwin I. Cohn & G.H.A. Clowes: Cohn's liver fraction G contained
the "active" material.
1929: William B. Castle: Described an "intrinsic factor" from stomach
needed to correct P A.
1938: Lucy Wills & Barbara Evans: Nutritional anemia in pregnant women
failed to respond to liver extract: thus, a second form of megaloblastic
anemia.
1943: II Pfiffner & ELR Stokstad: Identified growth factor in yeast and
green plants: Named it folic acid.
1947: Thomas Wood and Edward Rickes: Precipitated some "red junk"
from liver.
1948: Karl Folkers: Identified and crystallized Vitamin B12.

Infiltrative Diseases (Amyloid,
Hemochromatosis Fabrys, Sarcoid)